High Protein Pepperoni Bread Recipe

Nothing beats the smell of fresh pepperoni bread baking in my kitchen on a lazy Sunday afternoon. This irresistible pepperoni bread recipe transforms simple pantry ingredients into the ultimate comfort food that disappears faster than I can slice it.

Last month, my teenage son brought three friends over after soccer practice, and they devoured an entire loaf in minutes. That’s when I knew this recipe was truly special. The combination of savory pepperoni, gooey melted cheese, and tender bread creates pure magic that brings families together around the dinner table. Whether you’re hosting game day gatherings or need a satisfying snack, this pepperoni bread delivers restaurant-quality flavor with homemade love—just like our ultra-savory crispy hash brown waffles do at brunch. Let’s get cooking!

Why You’ll Love This Pepperoni Bread Recipe

I’ve been making this pepperoni bread for over five years, and it never fails to impress my family and friends. The recipe comes together in just 15 minutes of prep time, making it perfect for busy weeknight dinners or last-minute entertaining. The tender, fluffy texture contrasts beautifully with chunks of savory pepperoni and two types of melted cheese that create those irresistible stretchy pulls. Unlike store-bought alternatives, you control every ingredient, ensuring fresh flavors and the perfect balance of spice. This bread freezes wonderfully for up to three months, so I always make extra batches for easy meal planning. My favorite part is how versatile it is – serve it warm as an appetizer, pair it with soup for a complete meal, or even enjoy with our cottage cheese alfredo for a creamy, protein-packed twist.

Storage & Serving Tips

Store your pepperoni bread at room temperature in an airtight container for up to three days, or refrigerate it wrapped tightly for one week. Pro tip: I recommend reheating slices in a 350°F oven for 5-7 minutes to restore that crispy exterior and melted cheese center. For the best flavor experience, serve this bread warm with marinara sauce for dipping, or pair it alongside minestrone soup for a hearty meal. The bread also works beautifully sliced into bite-sized pieces for charcuterie boards and party appetizers. In my experience, letting the bread cool for at least 10 minutes before slicing prevents crumbling and ensures clean, perfect slices every time.

Conclusion

This pepperoni bread recipe proves that the most satisfying comfort foods often come from the simplest ingredients. With its tender crumb, savory filling, and irresistible aroma, it’s guaranteed to become a household favorite. Give this recipe a try, and watch it disappear as quickly as it does in my kitchen!

Irresistible Pepperoni Bread Recipe

Savory pepperoni bread with melted cheese, perfect for snacks, appetizers, or comfort food meals

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Prep Time 15 minutes mins

Cook Time 35 minutes mins

Total Time 50 minutes mins

Servings: 10 slices

Course: Appetizer, Bread, Snack

Cuisine: American, Italian-American

Calories: 285

Ingredients Equipment Method Notes

Ingredients

  

• 1 whole egg
• 1 egg yolk
• 1.5 cups whole milk
• 3 tablespoons sugar
• 3 tablespoons vegetable oil
• 3 cups all-purpose flour
• 0.75 teaspoon salt
• 4 teaspoons baking powder 1 tablespoon plus 1 teaspoon
• 6 oz pepperoni chopped, thin slices preferred
• 2 cups shredded cheese 50% Mozzarella, 50% Provolone
• 1 teaspoon oregano or Italian seasoning
• 2 tablespoons butter optional, for brushing
• 1 teaspoon garlic paste or 1/4 teaspoon garlic powder, optional

Equipment

• Large mixing bowls
• Loaf pan
• Whisk
• Wire cooling rack

Method

 

1. Preheat your oven to 375°F (190°C). Grease a loaf pan or line it with parchment paper.
2. In a large bowl, beat the whole egg and egg yolk together. Add the milk, sugar, and vegetable oil. Mix well until combined.
3. In another bowl, whisk together the flour, salt, black pepper, and baking powder.
4. Gradually add the dry ingredients to the wet mixture, stirring until just combined. Don’t overmix.
5. Fold in the chopped pepperoni, shredded cheese, oregano (or Italian seasoning), and garlic (if using). Mix until evenly distributed throughout the batter.
6. Pour the batter into the prepared loaf pan, smoothing the top. If desired, melt the butter and brush it on top for extra flavor and golden finish.
7. Bake in the preheated oven for 30-35 minutes, or until the top is golden brown and a toothpick inserted in the center comes out clean.
8. Allow the bread to cool in the pan for 10 minutes before transferring it to a wire rack to cool completely.
9. Slice and serve warm for the best experience!

Notes

Store at room temperature for up to 3 days, refrigerate for up to 1 week, or freeze for up to 3 months. Serve warm with marinara sauce for dipping. Perfect for game day, appetizers, or comfort food meals.